It is necessary to understand the interaction of fibrin coagulation pathways and platelet aggregation. Once we understand these interactions we can then discuss current treatment modalities. My goal is to show you a more creative and natural approach to anti-coagulation.
Initial Platelet Aggregation
In part one I emphasized the importance of platelet aggregation as the initial step. There is an initial injury to an arterial or venous wall. As a response, activated platelets cause a clumping reaction to repair the injury. Somewhat like Hans Brinker’s “finger in the dike.”
This injury could be a laceration. It could be a rupture of a atheromatous plaque. It could simply be a tear in an arterial wall. Or simply from low-flow stasis. Atrial fibrillation is an example.
You can see from fig 2 above that the platelets initiate an array of reactions. I will elaborate even more detail in the next post. This is ever-increasing overview.
Aspirin is the most common drug to prevent platelet aggregation. We will look at an array of drugs that have been used over the years. But there is a more creative approach.
Once the initial platelet plug has formed the long-term fibrin coagulation pathway is initiated. …