Browsed by
Month: October 2016

Vitamin K, Calcification and GLA Proteins

Vitamin K, Calcification and GLA Proteins

Vitamin K2 is a potent anti-calcification nutrient via GLA protein carboxylation.  Let’s look at this process of calcification and the potency of these various forms of vitamin K2.   Then talk about the MK-4 vs Mk-7.    Which is best for you?   And why?

Vitamin K2 forms

There are currently three forms of vitamin K available. Vitamin K1 (phylloquinone) has been extensively studied. It is not the most potent form. Vitamin K2 is currently available in two forms. MK-4 also known as menaquinone-4 or menatetranone. MK-7 (menaquinone-7) is currently advocated as the most potent form of vitamin K2. You can see in fig 1 that the MK-4 and MK-7 have long “tails” with multiple (poly unsaturated) double bonds.  This increases lipid solubility.  These are fat soluble as opposed to water vitamins.

Vitamin K1 and vitamin K2 MK-4 MK7
fig 1

So what is the connection between Vitamin K2 and tissue calcification? Why do we petrify as we grow older? Why do we grow stiffer? This is a combination of calcification and glycation.  Glycation is secondary to excess carbohydrates, rising hemoglobin A1c (>5.6%), and impaired fasting blood sugars (>100 mg).

Calcification is an impaired healing process. Arterial injuries initiate a process of calcium deposition as a repair mechanism. Calcification is the end result of chronic inflammatory processes.   This is a key concept.

How can we prevent or reverse this ossification process?

Read More Read More


Enjoy this blog? Please spread the word :)