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Tag: statins

Relative Risk vs Absolute Risk Reduction

Relative Risk vs Absolute Risk Reduction

I have written often and spoken repeatedly to so many of my patients about relative versus absolute risk.  This is so widespread in the medical literature, scientific literature and even in all advertising.  I am always waiting for that “aha moment” when you understand how relative risk management is chicanery.  It is used to sell you product.  To amplify, inflate or conflate results. I am prompted to write this blog by a recent meta-analysis published in JAMA Neurology May 13,…

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Is Cholesterol the Culprit?

Is Cholesterol the Culprit?

 Probably as long as you can remember, cholesterol is “known” to be the cause of cardiovascular (heart and blood vessel) disease.  Does dietary cholesterol cause heart disease?  What about familial super high cholesterol?  Does that cause heart disease?  The short answer is – probably not.  Let’s expand.  I have written extensively on the subject in the past. Cholesterol has been studied since the early 1900s.  Initially in fits and starts. John Goffman studied cholesterol in the 1950s at Donner labs…

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Statins: A Critical Appraisal

Statins: A Critical Appraisal

You can find a number of well written books with articulate statistical analyses over the years questioning the results of statin therapy.   What is the true value and efficacy of statins (HMG-CoA reductase inhibitors) in treating and preventing heart disease?   The statistics can be overwhelming.   What is the real risk benefit ratio? Lipids and the Emergence of Statin Therapy Lipid research actually started sometime in the early 1920’s.   It gained more momentum in the 1950’s with John Gofman at the…

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