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Iron Deficiency Signs and Symptoms -Part IV

Iron Deficiency Signs and Symptoms -Part IV

Symptoms of Iron Deficiency Anemia: Iron is essential for oxygen carrying capacity.  Iron deficiency and anemia decreases oxygen delivery to all major organs of the body. Most especially the brain, heart and muscles.   Iron deficiency manifests with easily identified symptoms and conditions.  Here is a quick overview followed by a more detailed description.   Mental Fatigue and Cognitive Impairment. Iron is an essential cofactor for neurotransmitter and myelin synthesis.  Brain neuronal cells require iron for DNA synthesis, mitochondrial respiration, and…

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Iron Therapy and Oxidative Free Radicals – Part III

Iron Therapy and Oxidative Free Radicals – Part III

We talked about the essentials of iron metabolism, iron uptake and iron control in part 1 and 2.  Now let’s try to unravel the mystery of iron therapy.  But first we take a side trip into oxygenation, reactive oxygen species (ROS) and free radicals. In reading through the literature it is obvious this is a very complex subject. Far more complex than is usually admitted. And I have alluded to many controversies where another binary choice is offered. Either you…

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Iron Regulation Part II: Transport Signaling

Iron Regulation Part II: Transport Signaling

All these years I was trying to understand the relationship between serum free iron, bound transferrin iron, storage as ferritin iron and anemia. What is the control mechanism?   What is the cause of iron deficiency?   How is this related to chronic anemia?  How much lab data do we need to determine true iron status?  OK. So let’s review iron cycling through each body compartment. Bivalent Iron You want lab data that measures all these forms of iron transport and storage…

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Iron Metabolism Part I: Sources, Transport, Testing

Iron Metabolism Part I: Sources, Transport, Testing

The Essentiality of Elemental iron Iron is essential for healthy red blood cell hemoglobin levels. Red blood cell hemoglobin is essential for oxygen transport. Oxygen and glucose are absolutely essential for brain function.  The topic of today’s review. I think iron metabolism, assimilation and transport is highly misunderstood. And the subject of great controversy.  Here is why. Hemoglobin is the essence of red blood cell function. And you can see in figure 1, iron is the essential core of hemoglobin….

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