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Iron Regulation Part II: Transport Signaling

Iron Regulation Part II: Transport Signaling

All these years I was trying to understand the relationship between serum free iron, bound transferrin iron, storage as ferritin iron and anemia. What is the control mechanism?   What is the cause of iron deficiency?   How is this related to chronic anemia?  How much lab data do we need to determine true iron status?  OK. So let’s review iron cycling through each body compartment. Bivalent Iron You want lab data that measures all these forms of iron transport and storage…

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Iron Metabolism Part I: Sources, Transport, Testing

Iron Metabolism Part I: Sources, Transport, Testing

The Essentiality of Elemental iron Iron is essential for healthy red blood cell hemoglobin levels. Red blood cell hemoglobin is essential for oxygen transport. Oxygen and glucose are absolutely essential for brain function.  The topic of today’s review. I think iron metabolism, assimilation and transport is highly misunderstood. And the subject of great controversy.  Here is why. Hemoglobin is the essence of red blood cell function. And you can see in figure 1, iron is the essential core of hemoglobin….

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