PostHeaderIcon Your Personal Supplement Prescription for Optimal Health

Supplementation Regimen Can Optimize Your Health

Personal supplement daily regimen for your health and vitality

Patients often ask how do you maintain your health and youthfulness? What do you personally take? I need to walk the walk and practice what I preach.  I need to set an example for you.

You can do this.  You may need our help and motivation.  There are many variations of this rigorous approach.  You do not need to follow this implicitly.   But the closer you can approximate this, the better your results.

For 20 years I have advocated the same routine. The basic approach is consistent. Variations on a theme. The Paleo diet. Low Carb. Modified Atkins diet. Basically high protein low carbohydrate.  You can read the classic Protein Power by Michael and Mary Eades.

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PostHeaderIcon Anticoagulant Natural Alternative

Novel anticoagulant regimen to prevent strokes and heart attacks

Natural Anticoagulant Regimen

A natural anticoagulant routine. How could this benefit you? How can you implement this? Why is this a time-proven alternative to conventional approaches?

Hopefully, you have read part1, part2, and part 3 of this 4 part series. Primers on coagulation and thrombosis. I have carefully explained the process of coagulation resulting in heart attacks and strokes. We have talked about platelet aggregation. Which then leads to fibrin aggregation. Which leads to the final clot. All clots cause obstruction. Obstruction causes heart attacks and strokes. How can we prevent this?

I have alluded to the most powerful natural anticoagulants. These include the following:

  • Nattokinase — 100 mg twice daily
  • Ginkgo biloba — 120mg daily
  • High-dose fish oils — 1 tablespoon (10 grams) daily
  • Vitamin E — 800-1200 units daily
  • Adequate hydration — many glasses of pure water daily

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PostHeaderIcon AntiPlatelet AntiCoagulant Drugs

Coagulation and Anticoagulatant Therapy

Read part I and part II of this series for background.  So you will have a basic understanding of coagulation pathways. Yes, it is complex.

Remember, coagulation or clotting starts with platelet aggregation.  That initiates the complex coagulation cascade. This causes the mature thrombus or blood clot. Aggregated platelets with a thick fibrin mesh causes the thrombus.  The thrombus causes heart attacks, strokes or thrombophlebitis.  Here is the final complete picture:

injury activates platelets causing thrombus formation

fig 1- click for full size

So let’s discuss anticoagulant therapy medications.

Antiplatelet Agents – Aspirin and Plavix are first line of defense

Figure 2 shows how we prevent platelet aggregation and activation at various stages.  Look at figure 1.  Aspirin has been the mainstay of antiplatelet therapy. There has been a succession of drugs over the last three decades. Newer antiplatelet drugs supersede older ones.  Are these true advances or simply marketing campaigns?

antiplatelet drugs classified by site of action. Aspirin and Plavix are the most common platelet inhibitors

fig 2 – click for full size

Aspirin has been well studied in the literature.  A full 325 mg dose will prevent platelet aggregation.  Over time, aspirin has significant adverse reactions. These are direct and indirect reactions. It can cause tinnitus (ringing or buzzing noises in the ear).   It can cause major gastrointestinal bleeding.   This is a significant problem.

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PostHeaderIcon Coagulation Heart Attack and Stroke ‚Äď Part 2

It is necessary to understand the interaction of fibrin coagulation pathways and platelet aggregation. Once we understand these interactions we can then discuss current treatment modalities. My goal is to show you a more creative and natural approach to anti-coagulation.

Initial Platelet Aggregation

activated platelet aggregation

fig 1

In part one I emphasized the importance of platelet aggregation as the initial step. ¬†There is an initial injury to an arterial or venous wall.¬† As a response, activated platelets cause a clumping reaction to repair the injury. ¬†Somewhat like Hans Brinker’s “finger in the dike.”

This injury could be a laceration. It could be a rupture of a atheromatous plaque. It could simply be a tear in an arterial wall.   Or simply from low-flow stasis.  Atrial fibrillation is an example.


platelet activating factor PAF

fig 2

You can see from fig 2 above that the platelets initiate an array of reactions.  I will elaborate even more detail in the next post.  This is ever-increasing overview.

Aspirin is the most common drug to prevent platelet aggregation.  We will look at an array of  drugs that have been used over the years. But there is a more creative approach.

Once the initial platelet plug has formed the long-term fibrin coagulation pathway is initiated.¬† Read the rest of this entry »

PostHeaderIcon Coagulation Stroke Heart Attack Part 1

Heart Attack and Stroke Coagulation Basics

Let’s talk about heart attack and stroke causes and the complexity of the underlying coagulation (clotting) pathways. ¬† ¬†What a heady subject. ¬† ¬†You need a PhD in medical hematology, just to fully understand the complexities of coagulation. ¬† So let’s work through this step by step. ¬†This will be a multi part series. ¬†I will help you achieve a clearer understanding. None of us wants to suffer a heart attack or stroke!

What causes these these catastrophic vascular events? What are the risks?  What medications are commonly used?    Why are they not necessarily the best or even the healthiest choice?   Can we assess risk benefit ratios?   And what are the natural herbal-based alternatives?  Ones that can be just as effective with fewer side effects and less costly.   This is what you will not hear from your personal internist, cardiologist or even family physician.

Blood Clot is a Thrombus or Embolus

A thrombus totally blocks (occludes) blood flow from activated coagulation factors

fig 1

A blood clot usually starts with an injury to a vascular wall.  This could be one of your arteries or veins.  An intricate series of reparative or reactive events is set in motion.   Your body tries to rapidly repair injury to the vascular wall.   Atrial fibrillation is an alternative source of thrombus formation.  In this instance, stasis and not injury, initiates the reaction.

Fig 1  above shows you a representation of the well formed blood clot. It has the potential for blocking blood flow (vascular occlusion) which deprives tissues distal to the block of vital cell oxygenation. The medical term is myocardial infarction or cerebral infarction. Cells die from lack of oxygen.

The initial early phase begins with activation and aggregation of platelets.

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PostHeaderIcon Hashimoto’s Thyroiditis and Reverse T3 Thyroid


Hashimoto's can affect normal T3 and T4 physiology]

Hashimoto’s Auto Immune Thyroiditis

Hashimoto’s is an auto-immune condition.¬† Where your body sees thyroid as “foreign” or “not self.” ¬†This stimulates production of antibodies against to your own thyroid.¬† There are a host of auto immune conditions including Sjogren’s (Sicca Syndrome). Lupus, Scleroderma, CREST Syndrome and Rheumatoid Arthritis.

[Important note: It is vital to recognize that the TSH test is being used as a screening test.¬† See previous blog.¬† It will not diagnose Hashimoto’s.¬† It will totally miss this condition for years.]

We measure two antibodies.¬† Anti-thyroglobulin (matrix of the thyroid gland) and TPO (thyroid peroxidase).¬†¬† TPO is essential to the conversion of T4 to T3.¬†¬† Either of these can rise with Hashimoto’s.¬†¬† It is more common to see a rise in the TPO.¬†¬†¬† This condition usually results in Hypothyroidism (under active thyroid) by interfering with the normal conversions.¬†¬† The normal flow is T4 converts to the active form T3.¬† The more technical term is Hashimoto’s Autoimmune Thyroiditis.¬† It can occasionally result in the opposite.¬† That is, hyperthyroidism (over active thyroid) during a more acute or sub acute inflammatory phase.¬†¬† Thyroiditis means inflammation of the thyroid.

What causes Hashimoto’s?¬† This is not really well known.¬† There are various theories.¬† You will read that there are genetic factors.¬† And, it is far more common in women than men.¬† It is quite unusual in men.


Speculative (unproven) theories

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PostHeaderIcon Tyranny of the TSH

The Tyranny of the TSH

Let’s talk about further thyroid testing.¬† In an effort to reduce laboratory costs and find ever cheaper methods of evaluating thyroid function, the TSH has become the more commonly accepted first line test with “reflex” follow-up.

Now this assumes three very important concepts.

  1. The feedback mechanism between the pituitary and the thyroid is intact and functional.
  2. It assumes a “normal distribution.” That is, a typical “bell shaped” curve of all values from low to high.
  3. That we can assign “reasonable” upper and lower cut-off values.

Idealized Thyroid Feedback

Refer to figure 1.  You can see that TSH is part of a functional feedback loop.   High values infer hypothyroidism (under-active thyroid) and low values infer hyperthyroidism (over active thyroid).   The TSH values are opposite (inverse) to thyroid activity.  A compensatory mechanism.

thyroid schema

fig 1

But there is human variation.  It is an idealized loop that is not as precise as an integrated circuit.  A result of overly simplified mechanistic thinking.  There are rare situations where hypothalamic dysfunction can cause very low TSH levels rather than feedback from low thyroid activity.  This is termed central hypothyroidism.

We have steadfastly maintained over the last 15 years that complete thyroid analysis should include a TSH, free T4 and a free T3.¬† Frequently adding the reverse T3 and thyroid antibodies.¬† Refer to our previous post.¬†¬† The TSH is a poor measure of free T3 — the active metabolite or driver of metabolic function.

What is a Normal Distribution?

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PostHeaderIcon Aging Research Topics and Meetings

Aging and Age-Related Conferences and Updates:


[We are indebted to John Furber for these timely and comprehensive updates on aging and anti-aging research, meetings and conferences]

(updated 9 April 2016)


Disease Drivers of Aging: 

2016 Advances in  Geroscience Summit

April 13-14, 2016, New York City

Co-sponsored by AFAR, GSA, NIH, NYAS


Cognitive Aging Conference

April 14-17, 2016, Atlanta, Georgia, USA


31st International Conference

Alzheimer’s Disease International

April 21-24, 2016, Budapest, Hungary


Biomedical Innovation for Healthy Longevity

April 25-28, 2016, St. Petersburg, Russia


There’s much more … Read the rest of this entry »

PostHeaderIcon The Why and How of Thyroid Dosing

Thyroid assessment and treatment

Your thyroid is a master controller of vital human functions.  It controls your rate of metabolism and is the seat of your immunity.     There is an array of firmly held opinions, explanations and approach to treatment.

Characterization and symptoms

Hypothyroidism, an under active thyroid gland,  is common and is a frequently under-treated or un-treated endocrine disorder.     It is characterized by any of a number of symptoms including:

  • fatigue
  • weight gain or inability to lose weight
  • depression
  • poor immunity
  • cold hands or feet
  • hair loss
  • dry skin
  • low body temperatures
  • constipation
  • cognitive impairment (foggy brain)
  • puffy eyelids or loss of lateral eyebrows

Thyroid Cascade and Control

The approach to thyroid disorders is steeped in tradition, dogma and lack of understating of basic physiology and biochemistry.

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PostHeaderIcon aging conferences update

Aging Related Conferences

[with special thanks to John Furber]

Aging Conference schedule

           A Look at the future of aging

Gerontological Society of America (GSA)

68th Annual Scientific Meeting

“Aging as a Lifelong Process”

November 18-22, 2015, Orlando, Florida

Abstracts due March 5, 2015.


Society for Redox Biology and Medicine: 22nd Annual Meeting.

November 18 – 22, 2015, Westin Waterfront Hotel, Boston, Massachusetts USA

Abstracts deadline: 1 Sep 2015


FDA Public Workshop

Neurodiagnostics and Non-Invasive Brain Stimulation Medical Devices Workshop, 

November 19-20, 2015


BIT’s 3rd Annual World Congress of Geriatrics and Gerontology Р2015 (WCGG-2015)

“New Action on Aging”

November 26-28, 2015, Kaohsiung, Taiwan


8th International Conference on Cachexia, Sarcopenia and Muscle Wasting

December 4-6, 2015, Paris, France


AAAAM 23rd Annual Congress & Exposition (A4M)

December 10 ‚Äď 13, 2015, Las Vegas, Nevada


Experimental Biology EB2016 (FASEB)

April 2-6, 2016, San Diego, California

Abstract deadline Nov 9, 2015

Early registration deadline for discount: March 1, 2016


Disease Drivers of Aging: 

2016 Advances in  Geroscience Summit

April 13-14, 2016, New York City

Co-sponsored by AFAR, GSA, NIH, NYAS 2016


Oxygen Club of California World Congress

Redox Medicine and Nutrition

May 4-6, 2016, University of California at Davis


Thirteenth International Symposium on Neurobiology and Neuroendocrinology of Aging

July 17-22, 2016, Gasthof Hotel Lamm, Bregenz, Austria

Organizer: Holly M. Brown-Borg, Ph.D., Univ of North Dakota

Early discounted registration before March 1, 2016



Gerontological Society of America (GSA)

69th Annual Scientific Meeting

November 16-20, 2016, New Orleans, Louisiana


Society for Redox Biology and Medicine: 23rd Annual Meeting.

Society for Free Radical Research International 18th Biennial Congress.

(SFRBM and SFFRI joint meeting)

November 16 – 19, 2016, San Francisco, California


21st IAGG World Congress of Gerontology and Geriatrics

‚ÄúGlobal Aging and Health: Bridging Science, Policy, and Practice.‚ÄĚ

July 23 – 27, 2017, San Francisco, California

GSA is the largest membership organization of IAGG and will serve as the host society for the IAGG World Congress. GSA will not convene its own Annual Scientific Meeting that year. IAGG convenes every four years.




Several other lists on related topics are at the following websites:

JenAge Information Centre:

The Oxygen Club of California:

Society for Free Radical Research International:

FASEB Scientific Meetings:

FASEB Science Research Conferences:

Gordon Research Conferences:

Keystone Symposia:

Alzheimer’s Research Forum:¬†

UCL Consortium for Mitochondrial Research:


A variety of biology-related conferences are listed at F1000 Posters: 



See some of the excellent interviews and lectures online at

For example:

**  Stem Cells on the Mesa

**  20 Jan 2011 Barzilai and Cuervo on The Science Network

**  Interview with Paul F. Glenn


Poster presenters might wish to deposit their posters in the Open Access F1000Research website, so that more people can see them.