Iron Therapy and Oxidative Free Radicals – Part III

Iron Therapy and Oxidative Free Radicals – Part III

We talked about the essentials of iron metabolism, iron uptake and iron control in part 1 and 2.  Now let’s try to unravel the mystery of iron therapy.  But first we take a side trip into oxygenation, reactive oxygen species (ROS) and free radicals. In reading through the literature it is obvious this is a very complex subject. Far more complex than is usually admitted. And I have alluded to many controversies where another binary choice is offered. Either you…

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Iron Regulation Part II: Transport Signaling

Iron Regulation Part II: Transport Signaling

All these years I was trying to understand the relationship between serum free iron, bound transferrin iron, storage as ferritin iron and anemia. What is the control mechanism?   What is the cause of iron deficiency?   How is this related to chronic anemia?  How much lab data do we need to determine true iron status?  OK. So let’s review iron cycling through each body compartment. Bivalent Iron You want lab data that measures all these forms of iron transport and storage…

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Iron Metabolism Part I: Sources, Transport, Testing

Iron Metabolism Part I: Sources, Transport, Testing

The Essentiality of Elemental iron Iron is essential for healthy red blood cell hemoglobin levels. Red blood cell hemoglobin is essential for oxygen transport. Oxygen and glucose are absolutely essential for brain function.  The topic of today’s review. I think iron metabolism, assimilation and transport is highly misunderstood. And the subject of great controversy.  Here is why. Hemoglobin is the essence of red blood cell function. And you can see in figure 1, iron is the essential core of hemoglobin….

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Flu Vaccine 10% Effective

Flu Vaccine 10% Effective

Flu vaccine may only be 10% effective this year?  That means 90% ineffective.  Tell me more. I am asked frequently by my patients, “do you suggest or advocate the flu vaccine.”   My simple answer is no.  I do not recommend flu vaccines.   I am middle of road on vaccines.  Some vaccines are essential.  No argument.  Tetanus boosters, MMR for measles, mumps and rubella, polio vaccine.  In my day we all had smallpox vaccination.   That is now history.   I can…

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Why Your Doctor Is Either Depressed or Retiring

Why Your Doctor Is Either Depressed or Retiring

Why Your Doctor Is Burned Out or Retiring There is a growing litany of acronyms and alphabet soup organizations and algorithms that are designed to confuse, obfuscate and subordinate physician discretionary thinking. Funneling physician thinking into more pre-defined and standardized patterns. With the notion that these patterns are always superior, more efficient and accurate.  More than traditional physician discretionary thought, observation and formulation of diagnosis and treatment plans. This dizzying array is one of the many reasons why virtually every…

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Compounding pharmacies – a vanishing breed

Compounding pharmacies – a vanishing breed

Compounding Pharmacies – Service like it used to be Why are my  prescription medication prices increasing and not reimbursed? Compounding pharmacies and the individualization of specific formulations is an integral part of antiaging, age management, functional medicine and similar holistic practices. There was a time in the distant past when most formulations were compounded. That is the source of the mortar and pestle that was so ubiquitous in all pharmacies. I think that symbol has vanished. The advantage of compounding…

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Minivelle Vivelle Shortages Explained

Minivelle Vivelle Shortages Explained

Minivelle and Vivelle continue to be in short supply in most pharmacies across the country.  Initially, I was not able to determine any reason. Nothing revealed by simple Google searches.  No FDA drug recalls.  Not evident from FDA drug shortage surveillance lists. Now, one of my astute and persistent patients was able to track down the reason.   The FDA has been very critical of testing and quality assurance methods for this product.  Adherence to CGMP.  Current Good Manufacturing Practices….

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Minivelle Vivelle Short Supply

Minivelle Vivelle Short Supply

Minivelle and Vivelle are severely backordered. We have not been able to determine the source of this short supply. It emanates from the manufacturer. This is not a local pharmacy problem it is not a distribution problem. For obscure reasons it is not being manufactured. We have not seen any recalls. The 0.1 mg dose is in most demand and in short supply. Many of you have been dispensed a generic form of estradiol patches. Mylan is the leading generic…

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Vitamin K, Calcification and GLA Proteins

Vitamin K, Calcification and GLA Proteins

Vitamin K2 is a potent anti-calcification nutrient via GLA protein carboxylation.  Let’s look at this process of calcification and the potency of these various forms of vitamin K2.   Then talk about the MK-4 vs Mk-7.    Which is best for you?   And why? Vitamin K2 forms There are currently three forms of vitamin K available. Vitamin K1 (phylloquinone) has been extensively studied. It is not the most potent form. Vitamin K2 is currently available in two forms. MK-4…

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Your Personal Supplement Prescription for Optimal Health

Your Personal Supplement Prescription for Optimal Health

Supplementation Regimen Can Optimize Your Health Patients often ask how do you maintain your health and youthfulness? What do you personally take? I need to walk the walk and practice what I preach.  I need to set an example for you. You can do this.  You may need our help and motivation.  There are many variations of this rigorous approach.  You do not need to follow this implicitly.   But the closer you can approximate this, the better your results. For…

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